Unveiling physiological functions of extended synaptotagmins
نویسندگان
چکیده
منابع مشابه
Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes
Extended synaptotagmins (E-Syts) are a recently identified family of proteins that tether the endoplasmic reticulum (ER) to the plasma membrane (PM) in part by conferring regulation of cytosolic calcium (Ca2+) at these contact sites (Cell, 2013). However, the mechanism by which E-Syts link this tethering to Ca2+ signaling is unknown. Ca2+ waves in polarized epithelia are initiated by inositol 1...
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Eukaryotic cells are compartmentalized into membrane-enclosed organelles with defined structure and functions. These organelles are separated from each other, and for a long time it was thought that communication between them is confined to vesicular traffic or to exchange of membrane lipids by cytoplasmic transfer proteins. Recently, however, it has become apparent that organelles hitherto not...
متن کاملLoss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility
The extended synaptotagmins, E-Syt1, 2 and 3, are multiple C2 domain membrane proteins that are tethered to the endoplasmic reticulum and interact in a calcium dependent manner with plasma membrane phospholipids to form endoplasmic reticulum - plasma membrane junctions. These junctions have been implicated in the exchange of phospholipids between the 2 organelles. The E-Syts have further been i...
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The time t maps of Hamiltonian flows are symplectic. The order n Taylor series approximation with respect to initial conditions of such a map is symplectic through terms of order n. Given an order n Hamiltonian symplectic map, there are a variety of procedures, called symplectification methods, which produce exactly symplectic maps with Taylor series that agree with the initial Taylor map throu...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2015
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2015.1010951